Note. This list of Ministers is complete and subject to review when new appointments are made or a Pesidential reshuffle.
| Minister of Education | Prof Jane Nana Opoku Agyemang |
| Minister of Interior | Mark Owen Woyongo |
| Minister of Local Government and Rural Development | Julius Debrah |
| Minister of Women and Children's Affairs | Nana Oye Lithur |
| Ministry of Energy and Petroleum | Mr. Emmanuel Armarh Kofi Buah |
| Minister of Finance | Mr Seth Terkper |
| Minister of Trade and Industry | Ekwow Spio-Garbrah |
| Minister of Defence | Benjamin Bewa-Nyog Kunbuor |
| Minister of Roads and Highways | Alhaji Inusah Fuseini |
| Minister of Communication | Dr Edward Omane Boamah |
| Minister of Health | Dr. Kwaku Agyeman-Mensah |
| Minister of Food and Agriculture | Fifi Fiavi Franklin Kwetey |
| Minister of Justice and Attorney-General | Mrs. Marietta Brew Appiah-Oppong |
| Minister of Water Resources, Works and Housing | Alhaji Collins Dauda |
| Minister of Environment Science and Technology | Mr Akwasi Oppong-Fosu |
| Minister of Lands and Natural Resources | Nii Osah Mills |
| Minister of Transport | Mrs. Dzifa Attivor |
| Minister of Employment and Social Welfare | Haruna Iddrisu |
| Ministry of Foreign Affairs and Regional Integration | Ms Hannah Tetteh |
| Minister for Fisheries and Aquaculture Development | Madam Hanny-Sherry Ayittey |
| Ministry of Chieftaincy and Traditional Affairs | Dr. Henry Seidu Daanaa |
| Ministry of Youth and Sports | Mahama Ayariga |
| Minister of Tourism, Culture and Creative Arts | Mrs. Elizabeth Ofosu-Adjare |
| Minister of State | Alhaji Rashid Pelpuo |
| Minister of State | Mrs. Comfort Ghansah |
| Minister of State | Dr. Mustapha Ahmed |
| Minister of State | Elvis Afriyie- Ankrah |
| Minister of State | Alhassan Azong |
| Eastern |
Antwi Boasiako Sekyere |
| Ashanti |
Mr. Samuel Sarpong |
| Central |
Aquinas Quansah |
| Brong Ahafo |
Mr. Eric Opoku |
| Upper West |
Alhaji Amin Amidu Sulemani |
| Greater Accra |
Nii Laryea Afotey Agbo |
| Volta | Helen Adjoa Ntoso |
| Western |
Paul Evans Aidoo |
| Northern |
Alhaji Limuna Mohammed Muniru |
| Upper East |
Mr. James Zuugah Tiigah |
| General Seth Kofi Obeng | Former General Officer Commanding the Ghana Armed Forces |
| Mr Christopher Kobla Dewornu | Former Inspector General of Police |
| Professor John Nabilla | President of the National House of Chiefs |
| Nana Osei Asibey | Otumfuo Deebuosohene at the Manhyia Palace |
| Mr John Henry Martey Newman | Presidential Appointee |
| Dr Rabiatu Deinyo Ammah | Presidential Appointee |
| Mrs Cecilia Johnson | Presidential Appointee |
| Mr Patrick Enyonam Agboba (Togbe Sri III) | Presidential Appointee |
| Mr Rasheed Sulemana Mahama | Presidential Appointee |
| Okogyeman Kwaku Gyamprah III | Presidential Appointee |
| Mr David Kangah | Presidential Appointee |
| Mrs Ama Benyiwa-Doe | Presidential Appointee |
| Sir Dr Edward Nminyuor Gyader | Presidential Appointee |
| Pastor Abraham Kwaku Adusei | Presidential Appointee |
| Nana Saa Gyamfuaa II | Brong Ahafo Region |
| Nana Asiama Poku Afrifa II | Ashanti Region |
| Vo-Naa Bawah Mohammed Baba | Northern Region |
| Torgbui Binah Lawluvi VI | Volta Region |
| Rt Rev Dr Jacob Kofi Ayeebo | Upper East Region |
| Mr George Kofi Dadzie | Western Region |
| Guli-Naa Seidu Bhat Braimah | Upper West Region |
| Nana Kodua Kesse II | Eastern Region |
| Dr Percival Alfred Kuranchie | Central Region |