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Tekonline.org 8 years ago
(a) DRUG-DRUG INTERACTION
(b) MORE CANCERS
(C) TOXICITY TO THE HEART
(d) EFFECT ON THE ADOLESCENT BRAIN
(e)...
(a) DRUG-DRUG INTERACTION
(b) MORE CANCERS
(C) TOXICITY TO THE HEART
(d) EFFECT ON THE ADOLESCENT BRAIN
(e)...
Tekonline.org 8 years ago
Many of you might have heard of fatalities due to the consumption of anti-anxiety drugs and alcohol together. For example, unexpected deaths from taking Valium and drinking are quite common.
Furthermore, alcohol alters the ... read full comment
Many of you might have heard of fatalities due to the consumption of anti-anxiety drugs and alcohol together. For example, unexpected deaths from taking Valium and drinking are quite common.
Furthermore, alcohol alters the DOSE of almost any medication ingested, often with profound consequences.
Tekonline.org 8 years ago
"Alcohol and cancer: is drinking the new smoking?"
Cutting alcohol consumption linked to reduced cancer rates
CENTRE FOR ADDICTION AND MENTAL HEALTH
September 26, 2007 (Toronto) -
Researchers at the Centre for ... read full comment
"Alcohol and cancer: is drinking the new smoking?"
Cutting alcohol consumption linked to reduced cancer rates
CENTRE FOR ADDICTION AND MENTAL HEALTH
September 26, 2007 (Toronto) -
Researchers at the Centre for Addiction and Mental Health (CAMH) have clarified the link between alcohol consumption and the risk of head and neck cancers, showing that people who stop drinking can significantly reduce their cancer risk.
According to CAMH Principal Investigator Dr. Jürgen Rehm, existing research consistently shows a relationship between alcohol consumption and an increased risk for cancer of the esophagus, larynx and oral cavity. Dr. Rehm and his team analyzed epidemiological literature from 1966 to 2006 to further investigate this association and their results, published in the September issue of the International Journal of Cancer, showed that:
The risk of esophageal cancer nearly doubled in the first two years following alcohol cessation, a sharp increase that may be due to the fact that some people only stop drinking when they are already experiencing disease symptoms. However, risk then decreased rapidly and significantly after longer periods of abstention.
Risk of head and neck cancer only reduced significantly after 10 years of cessation.
After more than 20 years of alcohol cessation, the risks for both cancers were similar to those seen in people who never drank alcohol.
These results have important implications for tailoring alcohol policies and prevention strategies, especially for people with a family risk of cancer.
Said Dr. Rehm, "Alcohol cessation has very similar effects on risk for head and neck cancers as smoking cessation has on lung cancer. It takes about two decades before the risk is back to the risk of those who were never drinkers or never smokers."
Alcohol is the 'drug of choice' for Canadians, with 60% of Ontario adults consuming alcohol on at least a monthly basis. The direct and indirect costs to society of alcohol abuse are substantial: $5.3 billion in Ontario alone, second only to the social burden of tobacco. This burden takes into effect the cardioprotective effects of alcohol, which, unlike its link to cancer, has received a great deal of public attention.
Dr. Rehm notes that more research is needed on the effects of alcohol cessation on other types of cancer -- especially breast, liver and colorectal cancers, for which the International Agency for Research on Cancer has also classified alcohol as carcinogenic -- and on the effects of alcohol type, drinking patterns, and the joint effects of smoking and alcohol cessation on the risk of cancer.
Tekonline.org 8 years ago
Moderate alcohol use linked to heart chamber damage, atrial fibrillation in new study
Date:
September 28, 2016
Source:
University of California San Francisco
Summary:
Researchers have found that even moderate alco ... read full comment
Moderate alcohol use linked to heart chamber damage, atrial fibrillation in new study
Date:
September 28, 2016
Source:
University of California San Francisco
Summary:
Researchers have found that even moderate alcohol consumption may change the structure of the heart in ways that increase the risk of atrial fibrillation.
FULL STORY
Enjoy a glass of wine with dinner or a nightcap before bed, but don't count on their heart benefits.
A new study by UC San Francisco researchers found that even moderate alcohol consumption may change the structure of the heart in ways that increase the risk of atrial fibrillation.
"There's growing evidence that moderate alcohol intake may be a risk factor for atrial fibrillation, the most common heart rhythm disturbance in the world, but the mechanism by which alcohol may lead to atrial fibrillation is unknown," said Gregory Marcus, MD, endowed professor of atrial fibrillation research at UCSF and senior author of the study published Sept. 14, 2016, in the Journal of the American Heart Association.
Possible Pathway Between Alcohol and Atrial Fibrillation
Marcus and colleagues looked at damage to the left atrium of the heart as a possible pathway between alcohol and atrial fibrillation. Atrial fibrillation is a known risk factor for stroke. The irregular pumping of blood can lead to blood clots, which may travel to the brain and cause stroke.
The researchers evaluated data from more than 5,000 adults collected over several years in the Framingham Heart Study, including echocardiograms, medical history and self-reported alcohol intake. The study participants, mostly white and in their 40s to 60s, reported on average just over one drink per day. The overall rate of atrial fibrillation in the group was 8.4 cases per 1,000 people per year -- meaning over a 10-year period, eight out of 100 people were likely to develop atrial fibrillation.
Every additional drink per day was associated with a 5 percent increase in the yearly risk. Every additional drink per day also was associated with a statistically significant 0.16 millimeter enlargement of the left atrium, highlighting a possible site of physical damage caused by drinking.
Complex Relationship Between Alcohol and Heart Health
The new findings shed light on the complex relationship between alcohol and heart health -- one that likely precludes blanket advice on drinking habits, said Marcus.
Research has shown that moderate drinking can reduce the risk of heart attack while increasing the risk of atrial fibrillation. Marcus's team captured this conundrum in a study published earlier this year looking at hospital admissions in dry and wet counties of Texas. They found that patients in counties permitting alcohol sales were more likely to have atrial fibrillation but less likely to have heart attacks and congestive heart failure.
Alcohol's abilities to protect and harm the heart likely operate through different mechanisms and vary from person to person, said Marcus. The work in his group seeks to decipher these mechanisms, which will inform therapies for heart conditions and may ultimately enable physicians to give personalized advice to patients.
"I'm constantly trying to remind people that there are various forms of heart disease and not all are related to heart attack," said Marcus, who is also a practicing cardiologist. "Atrial fibrillation is growing in importance as our success in preventing heart attack grows."
He added that one pattern, revealed by UCSF's Health eHeart Study, is clear -- people who believe alcohol is good for the heart tend to drink more.
Story Source:
Materials provided by University of California San Francisco. Original written by Nina Bai. Note: Content may be edited for style and length.
Journal Reference:
David D. McManus, Xiaoyan Yin, Rachel Gladstone, Eric Vittinghoff, Ramachandran S. Vasan, Martin G. Larson, Emelia J. Benjamin, Gregory M. Marcus. Alcohol Consumption, Left Atrial Diameter, and Atrial Fibrillation. Journal of the American Heart Association, 2016; 5 (9): e004060 DOI: 10.1161/JAHA.116.004060
Tekonline.org 8 years ago
"Heavy alcohol use changes adolescents' brains"
Date:
December 8, 2016
Source:
University of Eastern Finland
Summary:
Heavy alcohol use during adolescence alters the development of brain, according to a recent stu ... read full comment
"Heavy alcohol use changes adolescents' brains"
Date:
December 8, 2016
Source:
University of Eastern Finland
Summary:
Heavy alcohol use during adolescence alters the development of brain, according to a recent study. Cortical thinning was observable in young people who had been heavy drinkers throughout their adolescence.
Share:
FULL STORY
Heavy alcohol use during adolescence alters the development of brain, according to a recent study from the University of Eastern Finland and Kuopio University Hospital. Cortical thinning was observable in young people who had been heavy drinkers throughout their adolescence. The findings were published in Addiction.
The study performed magnetic resonance imaging of the brain structure on young and healthy, but heavy-drinking adults who had been heavy drinkers throughout their adolescence, as well as on age-matched light-drinking control participants. They participated in three cross-sectional studies conducted over the course of ten years, in 2005, 2010 and 2015. The participants were 13 to 18 years old at the onset of the study.
All participants were academically successful, and the prevalence of mental health problems did not differ between the two groups. Although the heavy-drinking participants had used alcohol regularly for ten years, approximately 6-9 units roughly once a week, none of them had a diagnosed alcohol use disorder.
Magnetic resonance imaging of the brain revealed statistically significant differences between the groups. Among the heavy-drinking participants, grey matter volume was decreased in the anterior cingulate cortex bilaterally as well as in the right insula.
"The maturation of the brain is still ongoing in adolescence, and especially the frontal areas and the cingulate cortex develop until the twenties. Our findings strongly indicate that heavy alcohol use may disrupt this maturation process," says PhD Student Noora Heikkinen, the first author of the study.
Cingulate cortex has an important role in impulse control, and volumetric changes in this area may play an important role in the development of a substance use disorder later in life. Structural changes in the insula, on the other hand, may reflect a reduced sensitivity to alcohol's negative subjective effects, and in this way contribute to the development of a substance use disorder.
"The exact mechanism behind these structural changes is not known. However, it has been suggested that some of the volumetric changes may be reversible if alcohol consumption is reduced significantly. As risk limits of alcohol consumption have not been defined for adolescents, it would be important to screen and record adolescent substance use, and intervene if necessary."
Story Source:
Materials provided by University of Eastern Finland. Note: Content may be edited for style and length.
Journal Reference:
Noora Heikkinen, Eini Niskanen, Mervi Könönen, Tommi Tolmunen, Virve Kekkonen, Petri Kivimäki, Heikki Tanila, Eila Laukkanen, Ritva Vanninen. Alcohol consumption during adolescence is associated with reduced grey matter volumes. Addiction, 2016; DOI: 10.1111/add.13697
Tekonline.org 8 years ago
"Your Brain on Booze: Why Alcohol Makes the Brain Feel Good and Bad"
NEUROSCIENCE NEWS DECEMBER 21, 2015
Christmas festivities are now in full swing, with bleary heads aplenty. But what is the effect on our brains? ... read full comment
"Your Brain on Booze: Why Alcohol Makes the Brain Feel Good and Bad"
NEUROSCIENCE NEWS DECEMBER 21, 2015
Christmas festivities are now in full swing, with bleary heads aplenty. But what is the effect on our brains?
Scientists are only now beginning to unravel exactly why alcohol can prove so toxic to our brain cells.
“There has always been an assumption that alcohol rots your brain, but we need to know exactly how it does this,” explains Professor Anne Lingford-Hughes, chair in addiction biology from Imperial College London, who is at the forefront of research into alcohol’s effects on the brain.
“Not only are we increasingly realising that alcohol effectively shuts the whole brain down – and can even trigger inflammation within the brain – but we’re also seeing how long these effects last. This knowledge is crucial to understanding alcohol dependency, and giving people effective treatments.”
Here Professor Lingford-Hughes explains what happens to our brain when we have a drink.
Why that first sip tastes so good
That first swig of wine or beer rapidly causes changes in two types of brain chemicals. These orchestrate much of alcohol’s effects on our thoughts, feelings and coordination.
“One of these chemicals, called GABA, acts like a sedative to calm the brain down, while the other, called glutamate, excites the brain and makes it more active,” says Professor Lingford-Hughes.
Alcohol quickly increases GABA function, which is why a drink relaxes us.
The reason karaoke is easier with a drink
One of the brain areas first affected by this imbalance in GABA and glutamate is the frontal lobe, explains Professor Lingford-Hughes, which is found just behind the forehead, and governs traits such as attention, planning and impulsivity.
“The frontal lobe is exquisitely sensitive to alcohol – this is why people quickly become disinhibited. As they drink more, their ability to think straight and integrate all of their thoughts become lost.”
And then texting becomes trickier
One of the next areas of the brain to be affected is the cerebellum, which sits at the base of your brain at the back of the head, and is crucial to controlling movement.
“If you paralyse this through alcohol, your movements become uncoordinated, and your speech slurred. The muscles across your whole body become affected – even in your eyes. This is why your vision becomes blurred – although your eyes are still seeing fine in terms of vision, your eye muscles aren’t working properly so each eye isn’t looking in the same direction.”
Foggy memory and black outs
Those fuzzy memories from the night before are due to an imbalance in the part of the brain caused the hippocampus, which is vital for memory. “This area of the brain is sensitive to changes in glutamate, and so when levels start to swing out of control, it struggles to lay down new memories.”
In recovery
When we stop drinking, our brain struggles to re-adjust to the situation.
“Once alcohol is out of the blood stream, GABA function falls, but glutamate – which excites the brain – is still very high. This can lead to anxiety, shakiness and poor sleep. If you have been drinking very heavily, this sudden change can even lead to fits. Levels of another neurotransmitter in the brain – dopamine – are also affected which can lead to low mood.”
Image shows a brain scan from a person with alcohol dependencies.
Brain scan of alcohol dependent person revealing areas
(in blue) with less grey matter. Image adapted from the ICL press release.
And high glutamate levels are bad news for our brain cells.
“Large amounts can prove toxic, as it seems to destroy all the delicate connections between brain cells – rather like pruning back a shrub until just a bare stump is left.”
As a result, explains Professor Lingford-Hughes, the after-effects from the festivities can last long into January.
“If someone has had a heavy Christmas they’ll feel pretty rough as the alcohol is going out of their system and their brains begin to readjust. We’re still unsure how long this takes but it could be a number of days, if not weeks. It will certainly take longer the older you are, as the brain takes longer to recover.”
Although Professor Lingford-Hughes is not suggesting everyone abstains from alcohol over the festive period – for the sake of your brain cells she urges sticking to sensible amounts.
ABOUT THIS ADDICTION RESEARCH
Other investigators involved in the study were Tina Bilousova, Carol A. Miller, Wayne W. Poon, Harry V. Vinters, Maria Corrada, Claudia Kawas, Eric Y. Hayden, David B. Teplow, Charles Glabe, Ricardo Albay III, Gregory M. Cole, and Edmond Teng.
Source: Kate Wighton – Imperial College London
Ben 8 years ago
why this imposition of restrictions on our only source of pleasure
why this imposition of restrictions on our only source of pleasure
Tekonline.org 8 years ago
Good question.
But pleasure does not need to harm, and there are so many ways to obtain pleasure without any threat to our biological well being: writing beautiful poetry, composing a sweet melody, creating a stunning pai ... read full comment
Good question.
But pleasure does not need to harm, and there are so many ways to obtain pleasure without any threat to our biological well being: writing beautiful poetry, composing a sweet melody, creating a stunning painting, a walk in a romantic garden, making a very cool app, engaging in scientific research, inventing something to positively change the lives of millions, just to mention a few.
Sam 8 years ago
Attend medical doctors annual dinner dance anywhere in the world and you would be shocked as to how much these "do gooders" enjoy the dreaded alcohol.
Attend medical doctors annual dinner dance anywhere in the world and you would be shocked as to how much these "do gooders" enjoy the dreaded alcohol.
Tekonline.org 8 years ago
One night's quaffing is most likely inconsequential.
It's the DAILY or WEEKLY overindulging that is a no-no.
One night's quaffing is most likely inconsequential.
It's the DAILY or WEEKLY overindulging that is a no-no.
So inspiring
LOOSE WEIGHT NATURALLY
Do you want to lose weight faster?
Do you want to flush out and eliminate toxins?0572174551
Do you want to have a nice shape?
Do you want to do more physical exercise without fatigue?
Wondering how ...
read full comment
(a) DRUG-DRUG INTERACTION
(b) MORE CANCERS
(C) TOXICITY TO THE HEART
(d) EFFECT ON THE ADOLESCENT BRAIN
(e)...
Many of you might have heard of fatalities due to the consumption of anti-anxiety drugs and alcohol together. For example, unexpected deaths from taking Valium and drinking are quite common.
Furthermore, alcohol alters the ...
read full comment
"Alcohol and cancer: is drinking the new smoking?"
Cutting alcohol consumption linked to reduced cancer rates
CENTRE FOR ADDICTION AND MENTAL HEALTH
September 26, 2007 (Toronto) -
Researchers at the Centre for ...
read full comment
Moderate alcohol use linked to heart chamber damage, atrial fibrillation in new study
Date:
September 28, 2016
Source:
University of California San Francisco
Summary:
Researchers have found that even moderate alco ...
read full comment
"Heavy alcohol use changes adolescents' brains"
Date:
December 8, 2016
Source:
University of Eastern Finland
Summary:
Heavy alcohol use during adolescence alters the development of brain, according to a recent stu ...
read full comment
"Your Brain on Booze: Why Alcohol Makes the Brain Feel Good and Bad"
NEUROSCIENCE NEWS DECEMBER 21, 2015
Christmas festivities are now in full swing, with bleary heads aplenty. But what is the effect on our brains? ...
read full comment
why this imposition of restrictions on our only source of pleasure
Good question.
But pleasure does not need to harm, and there are so many ways to obtain pleasure without any threat to our biological well being: writing beautiful poetry, composing a sweet melody, creating a stunning pai ...
read full comment
Attend medical doctors annual dinner dance anywhere in the world and you would be shocked as to how much these "do gooders" enjoy the dreaded alcohol.
One night's quaffing is most likely inconsequential.
It's the DAILY or WEEKLY overindulging that is a no-no.