Sub-Saharan African countries continue to struggle with chronic, year-round blood shortages, limiting their ability to support patients and deliver on the health-related Sustainable Development Goals (SDGs). 
 
Most blood recipients in sub-Saharan African countries are children and women around the time of childbirth,  So achieving the health-related SDGs depends on blood and blood product availability to reduce maternal mortality, end preventable deaths of newborn babies and children younger than 5 years, and achieve universal health coverage.

Blood shortages in sub-Saharan Africa can have devastating consequences. An estimated 70% of 287 000 pregnancy-associated deaths in the world in 2020 occurred in sub-Saharan African countries, predominantly due to obstetric haemorrhage. Insufficient blood supply for transfusion contributes substantially to such maternal deaths in hospitals in sub-Saharan Africa. 
 
Blood transfusions are also essential for managing sub-Saharan Africa's high rates of traffic accidents and childhood anemia, which is commonly due to infections such as malaria, helminthiasis, and haemoglobinopathies. Sub-Saharan Africa is home to more than 75% of the 300 000–400 000 babies born each year
globally with sickle cell disease;  Blood shortages contribute to 50–90% of these children dying before their fifth birthday. 
 
As health-care systems develop in sub-Saharan African countries, we can also expect increased blood needs for advanced cancer therapies, such as transplantation and cell therapy, organ transplant, dialysis, and cardiac surgeries.