The CAF Champions League and Confederation Cup entered the round four with TP Mazembe, Mamelodi Sundowns and Pyramids FC only sides to book their spot in the quarter-finals.
Here is a wrap of how Ghanaian players fared in the two continental competitions.
CAF CHAMPIONS LEAGUE
ISAAC AMOAH was an unused substitute for TP Mazembe when they came from a goal down to beat Angolan champions Primeiro de Agosto 2-1 in Lubumbashi on Saturday.
The DR Congo have booked their place in the quarter-finals of the competition after the win.
Former Hearts of Oak star ISAAC MENSAH played 68 minutes as Petro Atletico drew 2-2 with Moroccan giants Wydad AC at the Estadio 11 de Novembro in Angola on Saturday.
AS Vita Club suffered another home defeat at the Stade des Martyrs in when they were beaten 2-0 by defending champions Espérance de Tunis.
ZAKARIA MUMUNI started and played 66 minutes for the DR Congo giants on Saturday.
CAF CONFEDERATION CUP
Striker JOHN ANTWI came on as a substitute in the 65th minute for Pyramids FC to help the Egyptian moneybags to be the first side to secure a place in the quarter-finals with a 2-0 win over Al Masry SC in Cairo on Sunday.
Defender KEVIN OWUSU AMOH played full throttle for Zambian side Zanaco FC in their 3-0 thrashing of ESAE FC of Benin in Lusaka on Sunday.
EMMANUEL OKUTU lasted all the minutes of the game on the bench for the Zambian side.
DANIEL DARKWAH put in a 74 minutes shift for Enyimba International FC as they mauled Algerian side Paradou AC 4-1 in Aba on Sunday.
NANA BONSU kept the posts for Enugu Rangers FC when they were held by Mauritanian giants FC Nouadhibou to a 1-1 stalemate in Enugu on Sunday.
GODFRED ASANTE and ENOCK ATTA AGYEI enjoyed 90 minutes for Horoya AC as they travelled to Mali to hold Djoliba AC to a scoreless draw.
HUDU YAKUBU was an unused substitute for the Guinean giants on Sunday.
MOHAMMED SAABA GARIBA played all minutes for FC San Pedro but that wasn't enough for Ivorian side to avoid a 3-0 defeat in the hands of Hassania Agadir in Morocco on Sunday night.